Charles River Laboratories International, Inc.
Location
Massachusetts
Founded
1947-02-28
Website
Risk Signals
1070 news mentions monitored
Industry Context
This company is tracked across risk categories, including those related to its sector (e.g., Commercial Physical and Biological Research, Testing Laboratories), including supply chain integrity, ESG practices, labor disputes, and regulatory compliance.
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Recent Articles about Charles River Laboratories International, Inc.
Live alerts from global media, monitored by Business Radar
2023-07-07 (bakersfield.com)
DEADLINE ALERT for CRL, VIRT, CGC, CUTR: Law Offices of Howard G. Smith Reminds Investors of ...
BENSALEM, Pa., July 07, 2023 (GLOBE NEWSWIRE) -- Law Offices of Howard G. Smith reminds investors that class action lawsuits have been filed on behalf of shareholders of the following
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2023-06-28 (globenewswire.com)
CRL SHAREHOLDER ALERT: Jakubowitz Law Reminds Charles River Shareholders of a Lead Plaintiff Deadline of July 18, 2023
NEW YORK, June 28, 2023 (GLOBE NEWSWIRE) -- Jakubowitz Law announces that a securities fraud class action lawsuit has commenced on behalf of shareholders...
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2023-06-18 (bakersfield.com)
SHAREHOLDER ALERT: Pomerantz Law Firm Investigates Claims On Behalf of Investors of Charles ...
NEW YORK, June 17, 2023 (GLOBE NEWSWIRE) -- Pomerantz LLP is investigating claims on behalf of investors of Charles River Laboratories International, Inc. (“Charles River” or the “Company”) (NYSE: CRL).
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2023-06-12 (globenewswire.com)
Long-Term Investors of CRL, FIS, GL, NSC Alert: Johnson Fistel, LLP Encourages Investors to Submit Their Information Below
SAN DIEGO, June 12, 2023 (GLOBE NEWSWIRE) -- Charles River Laboratories International, Inc. Johnson Fistel, LLP is investigating potential claims on...
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2023-06-11 (forextv.com)
CRL Class Action Lawsuit Reminder: Kessler Topaz Meltzer & Check, LLP Reminds Charles River Laboratories International, Inc. (CRL) Investors of Pending Securities Fraud Class Action Lawsuit
RADNOR, Pa., June 10, 2023( GLOBE NEWSWIRE)— The law firm of Kessler Topaz Meltzer& Check, LLP( www.ktmc.com) informs investors that a securities class action lawsuit has been filed in the United States District Court for the District of Massachusetts against Charles River Laboratories International
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2023-06-08 (bakersfield.com)
DEADLINE ALERT for CRL, VIRT, CGC, CUTR: Law Offices of Howard G. Smith Reminds Investors of ...
BENSALEM, Pa., June 08, 2023 (GLOBE NEWSWIRE) -- Law Offices of Howard G. Smith reminds investors that class action lawsuits have been filed on behalf of shareholders of the following
Read more
2023-06-08 (bakersfield.com)
SHAREHOLDER ALERT: Pomerantz Law Firm Investigates Claims on Behalf of Investors of Charles ...
NEW YORK, June 07, 2023 (GLOBE NEWSWIRE) -- Pomerantz LLP is investigating claims on behalf of investors of Charles River Laboratories International, Inc. (“Charles River” or the “Company”) (NYSE: CRL).
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2023-05-28 (bakersfield.com)
SHAREHOLDER ALERT: Pomerantz Law Firm Investigates Claims On Behalf of Investors of Charles ...
NEW YORK, May 27, 2023 (GLOBE NEWSWIRE) -- Pomerantz LLP is investigating claims on behalf of investors of Charles River Laboratories International, Inc. (“Charles River” or the “Company”) (NYSE: CRL).
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2023-04-19 (globenewswire.com)
Investigation Alert CRL, FIS, GL, NSC: Johnson Fistel, LLP Encourages Long-Term Investors to Submit Their Information Below
SAN DIEGO, April 19, 2023 (GLOBE NEWSWIRE) -- Charles River Laboratories International, Inc. Johnson Fistel, LLP is investigating potential...
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2023-04-16 (globenewswire.com)
SHAREHOLDER ALERT: Pomerantz Law Firm Investigates Claims On Behalf of Investors of Charles River Laboratories International, Inc. - CRL
NEW YORK, April 16, 2023 (GLOBE NEWSWIRE) -- Pomerantz LLP is investigating claims on behalf of investors of Charles River Laboratories International,...
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2023-04-09 (bakersfield.com)
SHAREHOLDER ALERT: Pomerantz Law Firm Investigates Claims On Behalf of Investors of Charles ...
NEW YORK, April 09, 2023 (GLOBE NEWSWIRE) -- Pomerantz LLP is investigating claims on behalf of investors of Charles River Laboratories International, Inc. (“Charles River” or the “Company”) (NYSE: CRL).
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2023-03-30 (nature.com)
Precision-activated T-cell engagers targeting HER2 or EGFR and CD3 mitigate on-target, off-tumor toxicity for immunotherapy in solid tumors | Cancer
To enhance the therapeutic index of T-cell engagers (TCEs), we engineered masked, precision-activated TCEs (XPAT proteins), targeting a tumor antigen (human epidermal growth factor receptor 2 (HER2) or epidermal growth factor receptor (EGFR)) and CD3. Unstructured XTEN polypeptide masks flank the N and C termini of the TCE and are designed to be released by proteases in the tumor microenvironment. In vitro, unmasked HER2-XPAT (uTCE) demonstrates potent cytotoxicity, with XTEN polypeptide masking providing up to 4-log-fold protection. In vivo, HER2-XPAT protein induces protease-dependent antitumor activity and is proteolytically stable in healthy tissues. In non-human primates, HER2-XPAT protein demonstrates a strong safety margin (>400-fold increase in tolerated maximum concentration versus uTCE). HER2-XPAT protein cleavage is low and similar in plasma samples from healthy and diseased humans and non-human primates, supporting translatability of stability to patients.
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